Experiments that help reduce fatigue

Supplements, protocols, and habits for reducing fatigue and increasing energy, organized by what worked best for users

The aggregate picture

What we're seeing across everyone tracking fatigue

Fatigue is one of the most common reasons people come to Coco.

3,155
experiments started
65%
completion rate
47%
noticed a change
18%
made it routine
The full fatigue library

All fatigue experiments (13)

Emerging◆Supplement

Cordyceps for fatigue

A specific mushroom species with trial evidence for exercise capacity, best suited to functional fatigue rather than ME/CFS.

62% noticed a change378 tried
Moderate◆Supplement

CoQ10 and NADH for fatigue

Two supplements that feed the energy-production chain at different points, with trial evidence specifically in chronic fatigue syndrome.

61% noticed a change372 tried
Emerging◆Supplement

D-ribose for fatigue

A sugar that provides the backbone of ATP, with a strong metabolic rationale but only early, uncontrolled human evidence.

59% noticed a change281 tried
Moderate◆Supplement

B12 for fatigue

The active, neurologically available form of B12, taken sublingually to sidestep the absorption problems that leave some people functionally deficient.

59% noticed a change149 tried
Moderate◆Supplement

CoQ10 for muscle fatigue on statins

Statins lower cholesterol by blocking the same pathway that produces CoQ10, and there's real evidence that supplementing CoQ10 reduces the muscle pain and fatigue that are statins' most common side effect.

48% noticed a change263 tried
Moderate◆Supplement

Riboflavin (B2) for fatigue and energy metabolism

Riboflavin is a required cofactor in the mitochondrial reactions that generate ATP, and deficiency, more common than recognized in restricted diets, directly causes fatigue and reduced exercise capacity.

48% noticed a change135 tried
Emerging◆Supplement

Magnesium malate for fatigue

A magnesium form whose malate component feeds directly into the cellular energy cycle, with a mechanistic rationale in fibromyalgia.

47% noticed a change156 tried
Moderate◷Protocol

The 70% rule for fatigue

A structured pacing approach that keeps activity below a specific fraction of available energy to prevent post-exertional crashes.

47% noticed a change195 tried
Moderate◈Device

Compression garments for fatigue

For orthostatic fatigue, abdominal or waist-high compression addresses blood pooling that knee-high garments can miss or worsen.

40% noticed a change240 tried
Moderate◷Protocol

Iron and fatigue

Fatigue can persist at iron levels labs call normal; the research-backed target is higher than most testing flags.

38% noticed a change142 tried
Moderate◷Protocol

The caffeine nap

Caffeine takes about 20 minutes to kick in, so pairing it with a short nap means you wake just as it takes effect.

37% noticed a change374 tried
Moderate◎Lifestyle

Raising the head of your bed for fatigue

Tilting the whole bed, not just propping pillows, provides a mild nightly stimulus that may expand plasma volume in orthostatic fatigue.

36% noticed a change310 tried
Moderate◷Protocol

Heart-rate pacing for fatigue

For ME/CFS and long COVID, a heart-rate ceiling makes an invisible biological limit visible, helping prevent post-exertional crashes.

35% noticed a change160 tried
The top experiment

Cordyceps for fatigue, in practice

378
started
78%
completed
62%
noticed a change
18%
made it routine

Self-reported by Coco members. Not a clinical outcome.

See details

Run your own fatigue experiment

Coco tracks what you try, notices what changes, and tells you the truth about whether it's working for you.

Educational content only. Not medical advice. Talk to a clinician before changing treatment.